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Opioid activity is due to both equally small affinity binding on the parent compound and higher affinity binding of your O-demethylated metabolite M1 to µ-opioid receptors. In animal products, M1 is up to 6 moments additional powerful than tramadol in making analgesia and 200 moments much more potent in µ-opioid https://johnathancsgsd.thezenweb.com/how-benesdin-can-save-you-time-stress-and-money-70555936

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